Laboratory of Neural Circuit Genetics
Our research aims to uncover the genetic, environmental, and evolutionary mechanisms that govern brain development and neural circuit formation. We investigate how nutritional deficiencies and disease-causing mutations disrupt neuronal specification, connectivity, and function using human studies, animal models, single-cell genomics, and brain organoids. Our goal is to translate these discoveries into gene therapy-based interventions for neurodevelopmental disorders.
Our laboratory investigates the development, evolution, and dysfunction of major cortical projection systems, including callosal neurons in layer 2/3, corticospinal motor neurons in layer 5, and corticothalamic neurons in layer 6.Â
The schematic illustrates these key neuronal connections in the mouse brain.
