Role of amino acids in brain development

> Chicken & Mouse Model to Phenocopy Protein Energy Malnourished Situation & study its effect on gene expression,  metabolism & Cellular Specification in the developing brain

> Analysis of Cases of malnourished humans patients with MRI and other methods to understand the defects in better detail.

Genetic modeling & gene therapy against neurodevelopmental disorders 

> Analysis of whole exome seq data from human patient cases of neurodevelopmental disorder (NDD) particularly causing defects in neuronal tract such as CC, CTh, CST & AC.

> Modeling mutation in mouse using iGonad or direct in utero electroporation & study its impact on neocortical neurogenesis

> Using human primary neuron or patient derived culture/organoid to study its effect on specification & gene expression changes.

> Using AAV mediated gene expression manipulation to rescue the defects in 

Evolution of Cortico-Spinal Motor Neurons

>Analysis of Anatomy of CST tract across vertebrate species including humans 

> Using Spatial Seq and SC-RNA Seq data generation or analysis of already available data 

> Functional analysis of conserved genes crucial for CSMN evolution. 

> Map out genomic evolution that leads to diversity and conservation in CSMN & its Tract formation

> Over express CSMN genes in mouse model using AAV to rescue CST defects